The user of Focus Punch will tighten its focus before any other moves are made. If any regular move (with a higher priority than -3) directly hits the focused Pokémon, it loses its focus and flinches, not carrying out the attack. If no direct hits are made, Focus Punch attacks as normal.

Moves of lower priority than Focus Punch - for example Avalanche or Dragon Tail - will not cause the user to lose focus. The user will tighten their focus, Focus Punch will attack, then the opponent will use their lower priority move (and in the case of Avalanche, hit with double power).

When a Pokémon is holding Fightinium Z and uses its Z-Power, Focus Punch turns into All-Out Pummeling and has base power 200.